The prevalence of endometriosis in reproductive-aged women is 2% to 10%, while in those who have been through menopause, the prevalence is an estimated 2. 9% Secretory Endometrium 151 14. Similar to the cells normally found in the fallopian tube, the cells often have small hair-like projections called cilia. 2 mm thick (mean, 2. An endometrial polyp was found in 86. 11. . Discussion 3. 0% Exogenous. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. A menstrual cycle for one woman may last for a few days but for another woman may last a. We performed p16 immunostaining on 35 normal endometrial specimens and 32 EPs, six of which were associated with tamoxifen therapy. 6k views Reviewed Dec 27, 2022. 0001). After menstruation, proliferative changes occur during a period of tissue regeneration. g, branching), including cystically dilated Abundant stroma (Gland : Stroma ratio <2:1) Glands/cells identical to proliferative endometrium Often due to anovulatory cycles Disordered Proliferative Endometrium Gland crowding (Gland : Stroma ratio >2:1) Furthermore, 962 women met the inclusion criteria. Doctor's Assistant: Anything else in your medical history you think the doctor should know?Metaplasia is defined as a change of one cell type to another cell type. If the estrogen dose is low, there may also be a lesser degree of proliferation that is described as weakly proliferative. Disordered proliferative endometrium with glandular and. Endometrial hyperplasia is an abnormal proliferative response to estrogenic stimulation. Endometrial hyperplasia (EH) is a proliferation of endometrial glands which is typically categorized into two groups: EH without atypia (usually not neoplastic) and EH with atypia (neoplastic; also referred to as endometrial intraepithelial neoplasia [EIN]). Ultrasound(pelvic and trans vaginal) that homogeneous endometrium is seen measuring 5 - 6 mm. 4. The ratio of glands to stroma increases compared to the normal proliferative phase endometrium, exceeding the ratio of 3:1 in hyperplasia. 3k views Reviewed >2 years ago. The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown is often seen when there has been bleeding. Am now on progesterone 5 mgs per day tablet . The ratio of glands to stroma increases compared to the normal proliferative phase endometrium, exceeding the ratio of 3:1 in. Thank. (2) Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Changes also occur in the stromal cells, which undergo a characteristic decidualization reaction. what does that mean?1. It can be healthy or disordered depending on the rate of cell growth and shedding. The follicular phase of the female menstrual cycle includes the maturation of ovarian follicles to prepare one of them for release during ovulation. The mean endometrial thickness measured on each day of the proliferation curve correlated closely with the mean estradiol levels measured on that day (coefficient 0. 186 satisfied customers. What does a weakly proliferative endometrium mean? It is probable that the presence of a weak proliferative pattern in a postmenopausal atrophic endometrium is a response of the uterine mucosa to continuous low level oestrogenic stimulation. Changes at the lower end of the histological spectrum are referred to as “disordered proliferative endometrium” (DPE), which describes a proliferative endometrium (PE) lacking the usual regularity of gland size and spacing. They described functional endometrium as being “weakly proliferative” or “weakly. PIP: Steroid sex hormones cause immediate changes in the endometrium. 5. Proliferative activity is relatively common in postmenopausal women ~25%. - Negative for polyp, hyperplasia, atypia or. This pattern may be seen in the perimenopausal years, or in postmenopausal years if there is a source of at least low-level estrogenic stimulation (e. The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. We have described the dynamics of the pattern of growth of. Asherman’s syndrome ( uterine adhesions) Endometrial cancer. Pearson x2, Fisher and Wilcoxon tests were used for statistical analysis as appropriate. resembling proliferative phase endometrium. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. In the 2003 World Health Organization. Hence, it is also known as Metaplastic Changes in Endometrial Glands. 72 mm w/ polyp. It is a special type of tissue that helps hold the other parts of the organ together. You might want to discuss low dose oral bcp's with your gyn or get a second opinion, as the bcp's stop all. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. 8% of hysteroscopies and in 56. Characteristics. . Eosinophilic and Ciliated Cell Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. The definition of a "normal menstrual cycle" is different for every woman. An endometrial polyp is a usually noncancerous growth attached to the inner wall of the uterus, common for women undergoing or who have completed menopause. read more. 10 ) [ 1 , 10 , 11 ]. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM. B. In addition, the term “carcinoma in situ” was proposed to describe small lesions, with or. 10170. There's been a Bank Holiday which usually delays issues. Wendy Askew answered. Definition. -- balls of condensed endometrial stroma. More African American women had a proliferative. Disordered proliferative endometrium with glandular and. 25% of patients with endometrial cancer had a previous benign EMB/D&C. N85. In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. The study of endometrial carcinoma at menopause presents an interesting challenge. Decidualized endometrium is endometrium with changes due to progestins. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, some-what tortuous, with tall columnar pseudostratified(tend to diagnose disordered proliferative endometrium in perimenopausal years) •occasional dilated glands with proliferative activity, stromal breakdown, metaplasias (especially ciliated). Glands. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. It is also seen in exogenous estrogen therapy and is a result of dys-synchronous growth of the. Of the 71,579 consecutive gynecological pathology reports, 206 (0. 0001) and had a higher body mass index (33. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. Glands/cells identical to proliferative endometrium Abundant stroma Gland:Stroma ratio often 1:1, if becomes >2:1, then consider hyperplasia (see endometrial tumor notes) Often coinciding breakdown Endometrial glands and stroma outside of their usual endometrial cavity location→cause dysmenorrhea and/or menorrhagia AdenomyosisAtrophic endometrium is a normal finding in prepubertal, postmenopausal, and some perimenopausal women. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. Definition and Classification. The stromal cells are arranged in a compact manner. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. The uterus is the hollow, pear-shaped pelvic organ where fetal development happens. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. satisfied customers. -- abundant neutrophils and blood. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma. 5. Endometrial polyps are common and usually benign. Normal cyclical endometrium showed patchy glandular staining and there was also focal stromal p16 expression in the functional layer of most proliferative and secretory endometria. is this something t?" Answered by Dr. MD. DIAGNOSTIC APPROACH. read more Estrogen only: weakly to markedly proliferative endometrium, stromal breakdown, squamous morules Progestogen only: scant literature, secretory pattern (mildly tortuous glands with basal nuclei and scant luminal secretions) not always present Combined: Sequential: Weakly proliferative (small tubular glands with occasional mitoses) Endometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysis Endometrial cancer is a common gynecological malignancy that can affect the uterus and other organs. 1646 postmenopausal women aged 55-96 (mean 64. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. It's a long-term condition that can have a significant impact on your life, but there are treatments that can help. The immunohistochemical staining pattern for CD138 with appr. received endo biopsy result of secretory, focally inactive endometrium, neg for hyperplasia and malignancy. This condition is detected through endometrial biopsy. ". Europe PMC is an archive of life sciences journal literature. 4 × 10 −3 mm 2 /s,. Obstetrics and Gynecology 32 years experience. Diagnosis: Diagnosis: Fragments of weakly proliferative/inactive endometrium. Endometriosis can reactivate after menopause, particularly if estrogen levels rise again, such as after starting hormone replacement therapy. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. Then ovulation occurs. Many people find relief through progestin hormone treatments. Fibroids (benign uterine muscle growths) and polyps (endometrial masses) often cause no symptoms. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. Adenofibromas most commonly occur in postmenopausal women but the age range is wide. Endometrium, EMC Final Diagnosis A. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. what does that mean? 1 doctor answer • 1 doctor weighed in What do these endometrial biopsy results mean:diagnosis: endometrium, biopsy - scant strips of inactive glandular epithelium admixed with inflamed mucus, keratin debris and blood. What is the meaning of proliferative endometrium? The proliferative endometrium stage is also called the follicular phase. Learn how we can help. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. The endometrium is a sensitive target tissue for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility. Gurmukh Singh answered. ( I have had 5 endometrium biopsies over past 4 years and one D&C 6 years ago) • 01-2021 Endo Biopsy Diagnosis: Pre-hyperplasia, Disordered proliferative endometrium without atypia. 5 to 7–8 mm during the mid-proliferative phase ( 17 ). Re: What is weakly proliferative endometrium. In the endometrial carcinoma, the staining signal was. Results: All postmenopausal endometria were atrophic, but only 42 were inactive; of the remaining samples, 22 were weakly proliferative and 20 were mixed active and inactive. Share. Endometrial biopsies can help identify the presence of these types of abnormal tissues. PMID: 11584479. It aims to clarify the diagnostic criteria and differential diagnosis of these lesions, as well as their possible association with endometrioid neoplasia. It is a normal finding in women of reproductive age. doi: 10. Cytoplasmic vacuoles become supranuclear and secretions are seen within glandular lumina (Fig. Learn more about the causes, diagnosis, and treatment of this condition. There is, however, variation within the endometrial thickness depending on the vertical position of the tissue in relation to the surface epithelium and the endometrial–myometrial junction (Figure 14. 1, 2 They are the second most common uterine mesenchymal tumor after leiomyosarcoma. Atrophic endometrial cells, on the other hand, are smaller and more cuboidal than proliferative endometrium. 5. I had a biopsy with a d and c 15 weeks ago that was returned benign, negative for hyperplasia and carcinoma. 0% had weakly proliferative endometrial histology, 0. Endometrial changes of oral contraception, oral contraceptive effect, OCP endometrium, and endometrium with hormonal changes redirect here. They constitute less than 10% of all uterine malignancies and approximately 20% of all uterine sarcomas. X. Blood. 1,762. Microscopic (histologic) description. The secondary histologic features of chronic endometritis like gland architectural irregularity, spindled stroma, stromal edema and hemorrhage with the. your doctor should check your estrogen and LH and FSH hormone levels to see if they are normal. EH, especially EH with atypia, is of clinical significance because it may progress to. A Verified Doctor answered. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts. is this something t?. Disordered proliferative endometrium with glandular and stromal breakdown. Endometriosis often involves the pelvic tissue and can envelop the ovaries and fallopian tubes. g. 8 may differ. Endometrial stromal tumors (ESTs) are rare mesenchymal tumors occurring primarily in the uterine corpus. What is an endometrial polyp? An endometrial polyp is a non-cancerous growth found on the inside of the uterus. The study provides. Cancer can affect the uterus, the hollow, pear-shaped organ where a baby grows. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. Learn about the causes, symptoms,. Though there is a wealth of research into understanding the endometrial mechanisms involved in the implantation event, far less is known about the tissue’s regenerative properties, akin to. 0000000000005054. Endometrial Polyp B. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Epub 2023 Jan 4. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Because these cells appear unusual or "atypical" and because they may line. The histologic effect depends on the hormone, the potency, dosage, and the host receptor status. P type. focal mucinous metaplasia. postmenapausal weakly-proliferative endometrium with focal glandular crowding. These can lead to abnormal bleeding. Learn how we can help. I was diagnosed with disordered proliferative endometrium with glandular and stromal breakdown, benign polyps simple hyperplasia w/o atypia, a fibroid size of grapefruit pressing on bladder. 8 - other international versions of ICD-10 N85. This is essentially a normal report for your age. "Exodus" pattern is a term used to describe exfoliation of endometrial cells during the proliferative phase. It may be associated with abnormal menstrual bleeding or infertility. 78% cases) and. Characteristics. Barbara MacFarlane: : A secretory endometrium is at the end of the cycle and is. 2; median, 2. We performed an analysis of the development of proliferative phase endometrium in 246 cycles. The endometrium is obtained for evaluation by a process called dilatation and curettage or by endometrial biopsy. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. 0001) and had a higher body mass index (33. However, proliferative patterns observed in anovulatory premenopausal women or in postmenopausal women, if not corrected, signify an excess of estrogen that may place women at higher risk. The endometrium, a tissue of continuously changing patterns and immense proliferative activity during a woman’s reproductive life, becomes atrophic after the menopause as a result of ovarian failure. DIAGNOSTIC APPROACH. . Early diagnosis and treatment of EH (with or without atypia) can prevent progression to. Endometrial hyperplasia (EH) is a spectrum of morphological changes ranging from a slightly disordered pattern seen in the late proliferative phase of the menstrual cycle to the irregular proliferation of the endometrial glands with an increase in gland-to-stroma ratio leading to thickening of the endometrium []. While secretory changes in endometrial glands can be observed occasionally at birth, decidual or menstrual changes are rare ( 25 ). 3,291 satisfied customers. Menstrual bleeding between periods. MD. Dr R. 5. Over ten years if not treated, this can raise the risk of uterine malignancy. Dr. 3k views Reviewed >2 years ago. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). The mean follow. Van den Bosch et al 11 found that 14. Created for people with ongoing healthcare needs but benefits everyone. 2 mm thick (mean, 2. Baisal. Sometimes, adenomyosis causes no signs or symptoms or only mild discomfort. Learn how we can help. Furthermore, 962 women met the inclusion criteria. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. No malignancy was recognized. 81, p < 0. smooth muscle cells blood vessels. Re: Disordered Proliferative Endometrium. The endometrium represents the inner glandular epithelial lining of the uterus and provides a nourishing environment for possible implantation of the blastocyst. Endometrial biopsy showed a weakly proliferative Endometrium. At the same time, menopausal endometrium is. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Endometrial carcinoma is the most common malignant tumor in the female genital tract with an age-adjusted incident rate of 23. 4 It is a disease of ageing, with over 80% of cases occurring during the. Hysteroscopy is the gold standard to evaluate the endometrial cavity. 5 cm. One of the mechanisms thought to be involved when these entities are contributing to infertility is an adverse impact on endometrial receptivity. I. 11,672. The mean ADC value was 1. Dating of endometrium: Proliferative phase. Dr R. 5 years; P<. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. and 200 cases of endometrial samples with typical tubal metaplasia were followed for a mean of 64 and 61 months, respectively. The likelihood that women initially found to have proliferative changes were subsequently diagnosed with endometrial hyperplasia or cancer was almost 12%, some. This test is also used to identify uterine infections, such as endometritis . Endometrial cancer is a type of cancer that begins as a growth of cells in the uterus. Created for people with ongoing healthcare needs but benefits everyone. leiomyoma, other polypoid masses. 00524, p <0. Disclaimer: Information in questions answers, and. It says "weakly proliferative with stromal breakdown, negative for hyperplasia or carcinoma. Serous carcinoma is the prototypic endometrial carcinoma that is not related to estrogenic stimulation and typically occurs in the setting of endometrial atrophy. common. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. - Negative for. Normal proliferative endometrium contains glands that are regularly spaced and that lie within stroma at a gland: stroma ratio of 1 to 1. This is the American ICD-10-CM version of N85. Prolonged exposure to progesterone induces a rounded cell characterized. The unstained glands are irregularly dispersed with focal back-to-back crowding. Dr. Medical Director. 0; range, 1. Physician. Proliferative Dilated proliferative type glands, with pseudostratification Focal breakdown common Due to unopposed estrogen Irregularly Developed Secretory type glands co-exist with proliferative glands. Ed Friedlander and 4 doctors agree. Thank. Your provider can also use endometrial. 9% of them developed endometrial cancer or hyperplasia, a four-fold greater. Stroma is made up of cells that give the tissue its strength and shape. The mean age at which the patients were. Many of these cells are called fibroblasts and pathologists often describe them as spindle cells because they are long. . Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. 9 vs 30. 0001). Learn how we can help. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called endometrial hyperplasia. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. I'm sure your physician is monitoring your endometrial lining via biopsy or D&C to make sure that you aren't at increased risk of endometrial hyperplasia or pre-cancer of the endometrium. Conclusions: At least half of the disease free postmenopausal atrophic endometria show a weak proliferative pattern, either diffuse or focal, probably as a response to continuous. Proliferative endometrium with no atypia or malignancy Proliferative endometrium with no atypia or malignancy MDPA 100mg BD for 6 to 8 weeks 8 weeks 3. A repeat "d&c after ablation " is usually not going to produce different results. (b) On CD10 immunohistochemistry, the stroma stains positive, confirming endometrial-type stroma, while the endometrial glands are negative. cally, the endometrium may show a spectrum of change ranging from total atrophy (basalis layer only) to a weakly proliferative endometrium with occasional mitotic figures and a thin functionalis layer. Furthermore, 962 women met the inclusion criteria. just reading about or looking for understanding of "weakly prolif endometrium" was part of my biopsy results. Doctor of Medicine. This definition comprises various types of hormonally induced metaplastic changes in the endometrium observed both in benign and premalignant or malignant conditions [9,10,11]. Pseudoneoplastic glandular response of the female genital tract, first described by Javier Arias-Stella in 1954 as atypical endometrial changes associated with the presence of chorionic tissue ( AMA Arch Pathol 1954;58:112 ) Typically found in the endometria of postabortion curettings of intrauterine or extrauterine pregnancies or with. Endometrium: Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferativeDisordered proliferative Endometrial hyperplasia. Proliferative endometrium indicates the follicular phase; whereas, secretory endometrium indicates luteal phase. Dr. In this phase it is called Proliferative Endometrium. Blood. Painful intercourse (dyspareunia) Your uterus might get bigger. 451 views Answered >2 years ago. A: Low power view shows many morule formations in the endometrium. Adenofibroma. Women with a proliferative endometrium were younger (61. Demosthenes, MD. If you stopped the Prempro, the buildup would disappear, and the bleeding would go away. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. Adenomyosis is distinct from endometriosis, which is the presence of endometrial. 81, p < 0. 8% of hysteroscopies and in 56. Fibroids (benign uterine muscle growths) and polyps (endometrial masses) often cause no symptoms. What does this test result mean. 09–7. What does this mean? waiting to hear from doctor. when ovulation doesn't occur the endometrium becomes thick (proliferative), but without the progesterone release of. DDx. 5 per 100 000 women per year in the United States. SEE COMMENT. Adenofibromas most commonly occur in postmenopausal women, but the age range is wide. This was done in 3 parts: (1) retrospective chart review of all patients with reported insufficient or scant endometrial samples from 2010 to 2013 at our center to determine repeat sampling and final pathologic diagnosis; (2) survey of gynecologists about their practice for managing patients with these samples; (3) blind review of 99 cases of. does scant superficial strips of inactive endometrium seperate fragments of unremarkable squamous epithelium & mucus mean on an endometrial biops? 1 doctor answer • 2 doctors. 2 percent) By comparison, the background prevalence of endometrial pathology in postmenopausal patients without bleeding is lower. , 1985). When cancer grows in this lining, it is called. Created for people with ongoing healthcare needs but benefits everyone. The endometrium becomes thicker leading up to ovulation to provide a suitable environment for a fertilized egg to grow inside the uterus. Endometriosis is a condition where tissue similar to the lining of the womb grows in other places, such as the ovaries and fallopian tubes. In addition, the term “carcinoma in situ” was proposed to describe small lesions, with or. Glandular tissue usually inactive and of basalis or proliferative type endometrium, but one fourth is functional; hemosiderin is generally absent (Am J Obstet Gynecol 1971;110:275)Endometrial hyperplasia (EH) is categorized into two groups: EH without atypia and EH with atypia (also referred to as endometrial intraepithelial neoplasia [EIN]). Atrophic endometrium is a common finding in prepubertal and postmenopausal. The proliferative and hyperplastic endometrium was commonly reported. 2 vs 64. At the end of this stage, around the 14th. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. Glands. Endometrial polyps. The specimen is received in formalin and consists of fragments of soft tan hemorrhagic tissue with admixed mucus aggregating to 3. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. It refers toAn endometrial polyp was found in 86. A weakly proliferative endometrium with focal stromal breakdown typically indicates that the endometrial lining of the uterus is not thickening as it should during the menstrual cycle. 8 became effective on October 1, 2023. comment: sections show rare strips of inactive glandular epithelium? 2 doctor answers • 2 doctors weighed in. Uterine polyp and endometrial polyp redirect here. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. I was diagnosed with disordered proliferative endometrium with glandular and stromal breakdown, benign polyps simple hyperplasia w/o atypia, a fibroid size of grapefruit pressing on bladder. Created for people with ongoing healthcare needs but benefits everyone. Your GP probably hadn't had time or knowledge that the report was ready to read. EH with atypia is neoplastic and may progress or coexist with endometrial carcinoma. Methods. Fewer than 2% of cases of endometrial hyperplasia without cytological atypia progress to endometrial carcinoma, compared with 23% of cases of endometrial hyperplasia with cytological atypia that progress to carcinoma (atypical hyperplasia; Kurman et al. I'm sure your physician is monitoring your endometrial lining via biopsy or D&C to make sure that you aren't at increased risk of endometrial hyperplasia or pre-cancer of the endometrium. Specimen was received in formalin and consists of mucoid. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia.